Enzymes >>>> Violation of enzymatic activity

Violation of enzymatic activity.

The science of enzymes and enzymatic activity, enzymology, attributes somatic diseases (including hereditary ones) to the causes of disruption of enzymatic activity and malfunctions in the work of enzymatic systems. Aging processes also cause disorders of enzymatic activity. In fact, impaired enzymatic activity is understood as impairing the regulation of enzyme activity and / or problems of enzyme synthesis. When making a diagnosis, they talk about enzymatic deficiency .

Violations of the regulation of enzyme activity are associated with malfunctioning of the endocrine system, which regulates the work of enzymes and digestion processes through hormone-like substances.

Violations of enzyme synthesis are associated with insufficiency of the pancreas and liver. Many inflammatory diseases, as well as tumors of the stomach and intestines, impede the synthesis of enzymes in the gastrointestinal tract. Hypovitaminosis plays an important role in the disruption of enzymatic activity, since many vitamins are involved in fermentation processes as catalysts. Due to the fact that enzymes for digestion are synthesized not only by the glands of the digestive system, but also by representatives of the intestinal microflora, the digestion process can be disrupted during the development of intestinal dysbiosis .

In case of violation of enzymatic activity, the processes of digestion and absorption of food in the gastrointestinal tract change. The motor function of the intestine suffers, forced to transport food masses in an insufficiently chopped form.

Signs of impaired enzymatic activity:

Nausea and / or urge to vomit after eating,
Diarrheal disorders ,
Severity or pain in the stomach or intestines,
Signs of colitis,
Constipation or vice versa diarrhea,
Increased gas production (flatulence),
Stool containing undigested food particles,
Steatorrhea (feces with a high content of undigested fats, has an oily sheen, is not easily washed off),
Loss of appetite, weight loss.

Diagnosis of enzymatic disorders is carried out on the basis of a study of the biochemical composition of gastric juice, which determines the level of acidity and the presence of enzymes, analysis of feces (coprogram), study of blood serum and urine composition for the presence and level of enzymes.

Treatment of enzyme deficiency is carried out exclusively under the supervision of a physician - gastroenterologist. For treatment, enzyme preparations of various directions of action are used. Doses and drug combinations are adjusted individually, taking into account the history of diseases.

Synthetic analogs of enzymes provide invaluable assistance in correcting disturbances in the work and synthesis of enzymes. These enzymes have a high specificity (selectivity) of action and catalytic activity similar to those created by nature. But artificially created analogs do not have the properties of immune agents, and, therefore, do not take part in immune processes.

Enzymatic drugs are used in two cases: as replacement therapy (in large doses) and as adjuvant therapy (small doses).

Digestive enzymes in the form of preparations cannot be taken indefinitely, only by courses prescribed by a doctor, since they disrupt the natural secretion of enzymes (the body will gradually abandon the independent production of enzymes), and can also cause a decrease in the absorption of certain trace elements (for example, iron).

What are the preparations of digestive enzymes :

Enzyme preparations with one active ingredient (Gastenorm-forte, Vestal, Panzinorm-forte, Creon, Mezim-forte, Penzital, Bromelain);
Combined enzymes (Panzinorm, Mezim, Festal, Pancreatin, Wobenzym) - contain combinations of active ingredients.

Enzyme preparations may contain hydrochloric acid (Betaine) or not contain hydrochloric acid (Bromelain and others). With ulcers of the stomach and intestines, with increased sensitivity of the walls of the gastrointestinal tract, with colitis, with the danger of bleeding in the gastrointestinal tract, drugs with hydrochloric acid are not used.

In addition to drugs, enzymatic disorders (to a mild degree) can be corrected by consuming plants: papaya (contains papain), pineapple (contains bromelain), choleretic herbs. But choleretic agents are not always appropriate and safe. Questions about the use of choleretic drugs should be discussed with your doctor.