Medical supplies >>>> Nonsteroidal anti-inflammatory medicinal product - what are they?

Nonsteroidal anti-inflammatory medicinal product - what are they?

The antipyretic properties of willow bark infusions have been known in natural medicine since ancient times. This led to the discovery of salicylates, the first nonsteroidal anti-inflammatory drugs. In 1827, scientists isolated a glycoside from willow bark, which they named "salicin," after the Latin name Salix alba (white willow). In 1860, salicylic acid was artificially synthesized from this glycoside, and in 1869, acetylsalicylic acid (aspirin) was obtained from this acid—the first nonsteroidal anti-inflammatory medicinal product, which remains a highly regarded nonsteroidal anti-inflammatory medicinal product to this day.

A distinctive feature of acetylsalicylic acid and other salicylates is their triple therapeutic action: antipyretic, anti-inflammatory, and analgesic. At the current stage of pharmaceutical industry development, two generations of nonsteroidal anti-inflammatory medicinal product (NSAIDs) have already been developed, which are more advanced in their properties and are much more widely used in medical practice.

The antipyretic effect of NSAIDs is achieved by altering the excitability of heat-exchange regulators. This causes dilation of cutaneous blood vessels (capillaries) and increases sweating.

The anti-inflammatory effect of NSAIDs is due to their decongestant action, limiting the exudative and proliferative phases that accompany tissue inflammation. These medicinal product act on inflammatory mediators at the cellular level.

The analgesic effect of NSAIDs is mediated by their effect on pain caused by inflammation. Second-generation nonsteroidal anti-inflammatory medicinal product (NSAIDs) already have a pronounced analgesic effect, comparable to analgesics developed specifically for pain relief.

Nonsteroidal anti-inflammatory medicinal product have a broader effect on the human body. Some of them can be used to contract the smooth muscle of arterial vessels and weaken the contractility of smooth muscle organs such as the uterus.

Nonsteroidal anti-inflammatory medicinal product affect blood clotting, that is, they have an antiplatelet effect - they prevent blood thickening and the formation of blood clots.

First-generation NSAIDs had a limited duration of action, so many were taken several times a day. However, some first-generation NSAIDs have a prolonged action and are therefore taken once daily. Second-generation NSAIDs are limited to twice-daily dosing.

Nonsteroidal anti-inflammatory medicinal product, in addition to their vital properties, also have toxic effects, as they are excreted by the kidneys and undergo biochemical transformation in the liver. Long-term use of medications such as NSAIDs should be monitored by a physician based on an examination and identification of diseases and health conditions.