Bacteriophages >>>> Rules for the use of bacteriophage preparations

Rules for the use of bacteriophage preparations.

There are several rules for using a bacteriophage preparation:

Before use, shake the bottle and see if there is any sediment, if a sediment is observed, then the bacteriophage is not suitable for use.

Since the bacteriophage solution is stored in the refrigerator, it has a correspondingly much lower temperature compared to, say, room temperature, so it is unacceptable to use it cold. To heat the bacteriophage solution, you can leave the unopened bottle for a while at room temperature or, much faster, warm it in your hand. But at the same time, it is necessary to warm the dose volume that you are going to use. To do this, take with a syringe or pour out the required amount of bacteriophage from a bottle into a small thin-walled glass or a smaller bottle and hold it in your palm until you feel that the bottle (glass) has acquired a different temperature.

Due to the fact that the drug contains a nutrient medium, if carelessly opening the bottle, microorganisms from the environment can get inside the bottle, which will cause deterioration or turbidity of the drug, therefore it is necessary to wash your hands thoroughly, wipe the cap with an alcohol-containing liquid, remove the metal cap, without touching rubber stopper (do not remove with the stopper).

You can, without opening the cap (puncturing the rubber stopper with a needle), draw the required dose with a sterile syringe and pour it into a clean container (a glass or a smaller vial), but only the dose that needs to be consumed (you cannot pour the remaining solution back into the original bottle).

When removing the rubber stopper, do not place the inner surface on a table or on any other object.

After taking the required dose, close the bottle with a rubber stopper, do not store open, store only in the refrigerator at the specified temperature.

You can drop the bacteriophage solution with an ordinary, cleanly washed pipette, but do not lower the pipette into a common bottle, but pour the required amount of phage into another container.

When rinsing the mouth and throat, the bacteriophage foams a lot, so they take it into the mouth in small doses.

The bacteriophage preparation can be diluted with boiled water (room temperature) up to twice if necessary (for example, in order to check if there are any adverse reactions to the preparation: rashes, nausea - especially in children of the first months of life). But the dilution of a bacteriophage with water must be justified, since this changes the concentration of the number of phages in the solution, and for the lysis of even one bacterium, several tens of phages are needed.

Reproduction of a bacteriophage in the body occurs within 30 minutes and this is a chain reaction that lasts until no bacteria remain in a given area, therefore, it takes at least an hour for the bacteriophages to begin to act.

Bacteriophage solution is used for prophylactic purposes or clinical treatment of various bacterial infections. These diseases can be both purulent-inflammatory and enteral, but the main condition for their use is the presence in the body of a bacteria of the kind to which this type of bacteriophage is "sharpened", and the strains of which are preliminarily sown during bacteriological studies.