Bacteriophages >>>> Staphylococcal bacteriophage

Staphylococcal bacteriophage.

Refers to the pharmacological group of drugs: Medical immunobiological preparations (MIBP) - bacteriophage. It is produced in the form of a solution, used for oral administration, for rectal administration, local and external use in the form of applications, irrigation; is introduced into the nasal cavity, nasal sinuses, into the wound cavity, into the drained cavity, into the cavity of the vagina, uterus (the rules of use can be found here).

The preparation contains: active substance - sterile filtrate of phagolysates of bacteria of the genus Staphylococcus and auxiliary substances - preservatives 8-hydroxyquinoline sulfate or hydroxyquinoline sulfate monohydrate. Available in bottles of 20 or 100 milliliters. One pack contains 4 or 8 vials of 20 ml or one vial of 100 ml. It is necessary to store and transport the bacteriophage at a temperature of 2 to 8 C o in a place protected from light.

The drug is suitable for use within two years from the date of release, subject to the appropriate storage rules. But if, when buying a drug, the integrity of the bottles or labeling is violated, the solution becomes cloudy or a precipitate is observed, the shelf life has expired, then such a drug is not suitable for use.

Staphylococcal bacteriophage is a transparent liquid without sediment, yellow tint of varying intensity. It has biological properties to cause specific lysis (dissolves the membrane) of Staphylococcus bacteria strains.

The bacteriophage has no side effects, but can cause sensitivity to any components of the solution or intolerance. In such cases, the bacteriophage is contraindicated.

The bacteriophage can be used in combination with other pharmaceuticals, including antibiotics. Overdose of the drug has not been identified.

Staphylococcal bacteriophage is used for the treatment and prevention of various infections of a bacterial nature. It can be both purulent-inflammatory and enteral diseases, but the condition for use is the same - the presence of bacteria of the genus Staphylococcus, the strains of which are preliminarily detected during bacterial sowing.

Diseases with indications for the use of staphylococcal bacteriophage:

Diseases of the mouth, throat, nose, nasopharynx, ear, respiratory tract (sinusitis, pharyngitis, tonsillitis, bronchitis, laryngitis, pneumonia, pleurisy, tracheitis);
Infections after surgical interventions (festering wounds, burns, phlegmon, abscess, carbuncle, furuncle, panaritium, osteomyelitis, mastitis, paraproctitis, bursitis, hydroadenitis);
Urogenital infections (cystitis, colpitis, vaginosis, urethritis, pyelonephritis, salpingo-oophoritis, endometritis);
Enteroinfections (gastroenteritis, gastroenterocolitis, cholecystitis, intestinal dysbiosis);
Generalized septic diseases;
Purulent - inflammatory diseases in newborns (pyoderma, omphalitis, sepsis, conjunctivitis , blepharitis, gastroenterocolitis and others);
Many other diseases caused by staphylococcus bacteria.
In case of especially severe manifestations of staphylococcal infection, the drug is used in complex therapy along with other antibacterial agents.
For the prevention of wound infection, the drug is used in the treatment of freshly infected and postoperative wounds.
To prevent nosocomial infections, the drug is used as part of epidemiological measures.

Doses and rules of admission:

During pregnancy and breastfeeding, bacteriophage is used in doses recommended by a doctor.

In children under 6 months: (at one time) orally (by mouth) - 5 ml, rectally - 5-10 ml. When sepsis, enterocolitis occurs in children of this age (this also applies to premature babies), the bacteriophage is administered using high enemas - through a catheter or a gas outlet tube 2-3 times a day at a dose of 5-10 ml. If there is no regurgitation or vomiting, the drug can be administered orally, mixed with breast milk. A combination of rectal and oral administration of a bacteriophage is possible. Usually, the course of treatment lasts from 5 to 15 days. In case of relapses of the disease, there is an opportunity for repeated courses of treatment.

In the prevention of sepsis and enterocolitis with intrauterine infection or in case of a threat of nosocomial infection in newborns, the drug is used by enemas 2 times a day for 5-7 days.

For the treatment of omphalitis, pyoderma, infected wounds in children of this age, the drug is used daily as applications twice a day. In this case, a sterile gauze napkin is moistened in a bacteriophage solution and applied to the umbilical wound or to other affected skin areas.

In children from 6 to 12 months: (at one time) orally - 10 ml, rectally - 10-20 ml

In children from 1 to 3 years old: (at one time) orally - 15 ml, rectally - 20-30 ml

In children from 3 to 8 years old: (at one time) orally - 15-20 ml, rectally - 30-40 ml

From 8 years old and adults: (at one time) orally - 20-30 ml, rectally - 40-50 ml

In the treatment of purulent - inflammatory diseases with limited lesions, local treatment is carried out simultaneously and the drug is taken orally 2-3 times on an empty stomach one hour before meals, starting from the first day of the illness and for 7-20 days (according to indications).

If the wound was treated with chemical antiseptics before using the bacteriophage solution, then the wound is thoroughly washed with a sterile 0.9% sodium chloride solution before using the bacteriophage.

Depending on the localization of foci of infection, staphylococcal bacteriophage is used:

By irrigation, rinsing, lotions, tamponing in volumes up to 200 ml, depending on the size of the lesion. With an abscess, after removal of pus, a bacteriophage is injected into the wound by puncture in a smaller volume of removed purulent contents. In ostiomyelitis, after surgery, a solution of a bacteriophage with a volume of 10-20 ml is poured into the wound.

When a bacteriophage is introduced into the pleural, articular and other limited cavities, a volume of up to 100 ml is used, after which a capillary drainage is left, through which the bacteriophage is introduced for the required number of days.

In the case of cystitis, urethritis, pyelonephritis, the drug is taken orally. When draining the cavity of the renal pelvis or urinary bladder, the bacteriophage solution is injected through a nephrostomy or cystostomy up to two times a day, with doses of 5 to 7 ml into the renal pelvis, from 20 to 50 ml into the bladder.

For gynecological diseases of a purulent - inflammatory nature, the bacteriophage is injected into the vagina (uterus) in doses of 5-10 ml once daily, in the case of colpitis - 10 ml, irrigating or tamponing twice a day. The tampon is laid for two hours.

Purulent - inflammatory diseases of the nose, throat, ear require the use of a bacteriophage in doses of 2-10 ml from 1 to 3 times a day. In this case, the bacteriophage solution is used in the form of instillation, irrigation, rinsing, rinsing, and also the turundas soaked in it are injected into the nasal passage (or auditory canal) for an hour.

In cases of treatment of dysbiosis, enteral infections, bacteriophage is taken 1-3 times a day, one hour before the next meal. It is also possible to combine oral administration of a bacteriophage with rectal administration (using an enema after the bowel has been emptied) in combination with two oral doses and one rectal administration per day.